Publications from Persyst

  • Joshi, C. N., K. E. Chapman, J. J. Bear, S. B. Wilson, D. J. Walleigh, and M. L. Scheuer. “Semiautomated Spike Detection Software Persyst 13 Is Noninferior to Human Readers When Calculating the Spike-Wave Index in Electrical Status Epilepticus in Sleep.” J Clin Neurophysiol 35, no. 5 (Sep 2018): 370-74.
  • Scheuer, M. L., A. Bagic, and S. B. Wilson. “Reply To “What It Should Mean for an Algorithm to Pass a Statistical Turing Test for Detection of Epileptiform Discharges”.” Clin Neurophysiol 128, no. 7 (07 2017): 1408-09.
  • Scheuer, M. L., A. Bagic, and S. B. Wilson. “Spike Detection: Inter-Reader Agreement and a Statistical Turing Test on a Large Data Set.” Clin Neurophysiol 128, no. 1 (Jan 2017): 243-50.
  • Wilson, S. B. “Spike Detection Algorithm Performance and Methods of Acquiring Expert Opinion.” Clin Neurophysiol 121, no. 11 (Nov 2010): 1968-9; author reply 68.
  • Wilson, S. B. “Algorithm Architectures for Patient Dependent Seizure Detection.” Clin Neurophysiol 117, no. 6 (Jun 2006): 1204-16.
  • Wilson, S. B. “A Neural Network Method for Automatic and Incremental Learning Applied to Patient-Dependent Seizure Detection.” Clin Neurophysiol 116, no. 8 (Aug 2005): 1785-95.
  • Wilson, S. B., M. L. Scheuer, R. G. Emerson, and A. J. Gabor. “Seizure Detection: Evaluation of the Reveal Algorithm.” Clin Neurophysiol 115, no. 10 (Oct 2004): 2280-91.
  • Wilson, S. B., M. L. Scheuer, C. Plummer, B. Young, and S. Pacia. “Seizure Detection: Correlation of Human Experts.” Clin Neurophysiol 114, no. 11 (Nov 2003): 2156-64.
  • Wilson, S. B., and R. Emerson. “Spike Detection: A Review and Comparison of Algorithms.” Clin Neurophysiol 113, no. 12 (Dec 2002): 1873-81.
  • Guess, M. J., and S. B. Wilson. “Introduction to Hierarchical Clustering.” J Clin Neurophysiol 19, no. 2 (Apr 2002): 144-51.
  • Wilson, S. B., C. A. Turner, R. G. Emerson, and M. L. Scheuer. “Spike Detection Ii: Automatic, Perception-Based Detection and Clustering.” Clin Neurophysiol 110, no. 3 (Mar 1999): 404-11.
  • Wilson, S. B., R. N. Harner, F. H. Duffy, B. R. Tharp, M. R. Nuwer, and M. R. Sperling. “Spike Detection. I. Correlation and Reliability of Human Experts.” Electroencephalogr Clin Neurophysiol 98, no. 3 (Mar 1996): 186-98.

Selected research publications utilizing Persyst

  • Sharpe, C., S. L. Davis, G. E. Reiner, L. I. Lee, J. J. Gold, M. Nespeca, S. G. Wang, P. Joe, R. Kuperman, M. Gardner, J. Honold, B. Lane, E. Knodel, D. Rowe, M. R. Battin, R. Bridge, J. Goodmar, B. Castro, M. Rasmussen, K. Arnell, M. Harbert, and R. Haas. “Assessing the Feasibility of Providing a Real-Time Response to Seizures Detected with Continuous Long-Term Neonatal Electroencephalography Monitoring.” J Clin Neurophysiol (Oct 2018).
  • Halford, J. J., M. B. Westover, S. M. LaRoche, M. P. Macken, E. Kutluay, J. C. Edwards, L. Bonilha, G. P. Kalamangalam, K. Ding, J. L. Hopp, A. Arain, R. A. Dawson, G. U. Martz, B. J. Wolf, C. G. Waters, and B. C. Dean. “Interictal Epileptiform Discharge Detection in EEG in Different Practice Settings.” J Clin Neurophysiol 35, no. 5 (Sep 2018): 375-80.
  • Drohan, C. M., A. I. Cardi, J. C. Rittenberger, A. Popescu, C. W. Callaway, M. E. Baldwin, and J. Elmer. “Effect of Sedation on Quantitative Electroencephalography after Cardiac Arrest.” Resuscitation 124 (03 2018): 132-37.
  • Goenka, A., A. Boro, and E. Yozawitz. “Comparative Sensitivity of Quantitative EEG (Qeeg) Spectrograms for Detecting Seizure Subtypes.” Seizure 55 (Feb 2018): 70-75.
  • Goenka, A., A. Boro, and E. Yozawitz. “Assessing Quantitative Eeg Spectrograms to Identify Non-Epileptic Events.” Epileptic Disord 19, no. 3 (Sep 2017): 299-306.
  • Elmer, J., J. J. Gianakas, J. C. Rittenberger, M. E. Baldwin, J. Faro, C. Plummer, L. A. Shutter, C. L. Wassel, C. W. Callaway, A. Fabio, and Pittsburgh Post-Cardiac Arrest Service. “Group-Based Trajectory Modeling of Suppression Ratio after Cardiac Arrest.” Neurocrit Care 25, no. 3 (12 2016): 415-23.
  • Swisher, C. B., C. R. White, B. E. Mace, K. E. Dombrowski, A. M. Husain, B. J. Kolls, R. R. Radtke, T. T. Tran, and S. R. Sinha. “Diagnostic Accuracy of Electrographic Seizure Detection by Neurophysiologists and Non-Neurophysiologists in the Adult ICU Using a Panel of Quantitative EEG Trends.” J Clin Neurophysiol 32, no. 4 (Aug 2015): 324-30.
  • Fürbass, F., P. Ossenblok, M. Hartmann, H. Perko, A. M. Skupch, G. Lindinger, L. Elezi, E. Pataraia, A. J. Colon, C. Baumgartner, and T. Kluge. “Prospective Multi-Center Study of an Automatic Online Seizure Detection System for Epilepsy Monitoring Units.” Clin Neurophysiol126, no. 6 (Jun 2015): 1124-31.
  • Sierra-Marcos, A., M. L. Scheuer, and A. O. Rossetti. “Seizure Detection with Automated EEG Analysis: A Validation Study Focusing on Periodic Patterns.” Clin Neurophysiol 126, no. 3 (Mar 2015): 456-62.
  • Williamson, Craig A., Sarah Wahlster, Mouhsin M. Shafi, and M. Brandon Westover. “Sensitivity of Compressed Spectral Arrays for Detecting Seizures in Acutely Ill Adults.” Neurocritical Care20, no. 1 (February 2014): 32–39.


General References

  • Hirsch, Lawrence, Richard Brenner, and Richard P Brenner. Atlas of EEG in Critical Care. John Wiley and Sons, 2010.
    • A general reference with many cases illustrating the use of qEEG trends during cEEG monitoring, most  using Persyst software.
  • LaRoche, Suzette, and Hiba Arif Haider, eds. Handbook of ICU EEG Monitoring. Second edition. New York: Demosmedical, Springer Publishing Company, 2018.
    • A general reference with many figures illustrating the use of qEEG trends during ICU monitoring.
  • Richard Brenner, and Mark Scheuer. Adult EEG, Second Edition DVD: An Interactive Reading Session. 2nd edition. New York: Demos Medical, 2013.
    • An interactive teaching program featuring a set of carefully explained teaching cases in which qEEG trending is utilized.
  • Scheuer, Mark L, and Scott B Wilson. “Data Analysis for Continuous EEG Monitoring in the ICU: Seeing the Forest and the Trees.” Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society 21, no. 5 (n.d.): 353–78. .
    • Many people beginning to use qEEG find this article useful for general background information concerning some types of quantitative EEG assessments (e.g., aEEG, FFT spectrograms).
  • Schomer, Donald L., and F. H. Lopes da Silva, eds. “EEG in the Intensive Care Unit: Anoxia, Coma, Brain Death, and Related Disorders.” In Niedermeyer’s Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, Seventh edition., 610–58. New York, NY: Oxford University Press, 2018.
    • This chapter, from a classic EEG text, contains many figures utilizing Persyst qEEG trending.