Highlighted publication on Persyst 14 and its Seizure Detector
The release of Persyst 14 and its Seizure Detector was accompanied by the publication, “Seizure Detection: Interreader Agreement and Detection Algorithm Assessments Using a Large Dataset.”
This publication accomplished two things:
First, it established interreader agreement in a real-world environment. Three board certified neurophysiologists marked 120 prolonged (24-hour) EEGs for seizures. Marking was completely independent and without consensus discussions. The dataset was minimally selected and contained a mix of 100 consecutive seizure-containing records mixed with 20 seizure-free (though not necessarily normal) records.
In this study, the human experts achieved an average pairwise* sensitivity of 77% and a false-positive rate of 0.8 per day.
Pairwise* measurement of sensitivity and false positive rates across multiple readers is a statistical test, ultimately calculating the likelihood any two readers will agree with each other.
Additionally, compared to the previous studies that assessed interreader agreement,